Predictive Oncology Announces Significant Progress with FluGen In the Development of First-of-Its-Kind Intranasal Flu Vaccine

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As we dissect the latest update from Predictive Oncology, it's essential to consider the financial backbone surrounding such scientific endeavors. A grant of 6.2 million from the Department of Defense is not merely a financial boost but a stamp of credibility and trust in the project's potential. This influx of capital is expected to fuel the advanced phase of clinical trials, which is a pivotal stage in the developmental lifecycle of a new vaccine.

The biotech sector is highly responsive to advancements in clinical trials and the pursuit of a novel intranasal flu vaccine, particularly one backed by the DoD, can be seen as a harbinger of potential revenue streams for Predictive Oncology. The market for flu vaccines is competitive, but a product that can offer improved stability and a longer shelf-life could distinguish itself, hence potentially driving Predictive Oncology's market share and investor interest.

The stability and solubility of a vaccine formulation are not just scientific jargon but are critical to a vaccine's success. Predictive Oncology's focus on creating a stable, refrigerated formulation could revolutionize vaccine distribution, particularly in remote areas where logistics are challenging. From a medical standpoint, an intranasal vaccine represents a leap in administration methods, possibly improving public compliance and vaccination rates.

Investors should note the impact of this development. An accessible intranasal vaccine not only has the potential to disrupt the market but also to expand it significantly by simplifying the vaccination process. However, the long-term success hinges on clinical trial outcomes and the ability to scale production to meet global demand.

04/30/2024 - 04:05 PM

PITTSBURGH, April 30, 2024 (GLOBE NEWSWIRE) -- Predictive Oncology Inc.听(NASDAQ: POAI), a leader in AI-driven drug discovery and biologics, announces a collaboration with FluGen to bring a first-of-its-kind intranasal flu vaccine to market, as part of a $6.2 million Phase 2B grant awarded by the United States Department of Defense (DoD).

鈥淧redictive Oncology will play a critical role in helping to make our M2SR flu vaccine more stable and sustainable as we advance our clinical trials,鈥� says Paul Radspinner, President & Chief Executive Officer of FluGen. 鈥淭he project looks to hold tremendous promise.鈥�

Through a proprietary design of experiments, the Predictive Oncology biologics team will be developing a formulation that is soluble and stable in a refrigerated state, which is a vital part in the drug development process. Most importantly, this addresses the need for a longer vaccine shelf-life to support global distribution including remote locations. Predictive Oncology鈥檚 biologics capabilities are uniquely suited to help achieve maximum stability, one of the initial critical milestones.

鈥淲e are excited to advance these efforts for an intranasal flu vaccine that will be unlike any other on the market,鈥� notes Larry DeLucas, Senior Vice President of Biologics at Predictive Oncology. 鈥淯tilizing our exceptional technology and supported by our team of leading scientists, this work will allow FluGen to continue its clinical trials with greater potential to bring a more advanced and stable flu vaccine to patients.鈥�

About Predictive Oncology
Predictive Oncology (NASDAQ: POAI) is on the cutting edge of the rapidly growing use of artificial intelligence and machine learning to expedite early drug discovery and enable drug development for the benefit of cancer patients worldwide. The company鈥檚 scientifically validated AI platform, PEDAL, is able to predict with 92% accuracy if a tumor sample will respond to a certain drug compound, allowing for a more informed selection of drug/tumor type combinations for subsequent in-vitro testing. Together with the company鈥檚 vast biobank of more than 150,000 assay-capable heterogenous human tumor samples, Predictive Oncology offers its academic and industry partners one of the industry鈥檚 broadest AI-based drug discovery solutions, further complimented by its wholly owned CLIA lab and GMP facilities. Predictive Oncology is headquartered in Pittsburgh, PA.

About FluGen:
FluGen, Inc. is a clinical-stage vaccine company transforming vaccine efficacy in infectious respiratory diseases. The company鈥檚 lead candidate is M2SR, a supra-seasonal, live, single-replication, intranasal flu vaccine. Unlike standard of care flu vaccines, M2SR stimulates mucosal, humoral, and cellular immunity. In an unprecedented challenge trial, M2SR demonstrated protection against infection and illness across seven years of virus drift; and M2SR induces a durable antibody response with potential to cover an entire flu season and beyond. M2SR also has shown activity as a vaccine vector for other respiratory vaccines and infectious diseases, including a COVID-19/flu combination. For more information about FluGen, Inc., please visit听.

Contacts:听
Predictive Oncology Inc.听
Theresa Ferguson, Senior Director of Marketing听听
Phone: (630) 566-2003听
听

Predictive Oncology Investor Relations听听
Tim McCarthy听
LifeSci Advisors, LLC.
听

FluGen
Paul Radspinner
President & CEO
(608) 658-6095

Forward-Looking Statements:听
Certain matters discussed in this release contain forward-looking statements. These forward- looking statements reflect our current expectations and projections about future events and are subject to substantial risks, uncertainties and assumptions about our operations and the investments we make. All statements, other than statements of historical facts, included in this press release regarding our strategy, future operations, future financial position, future revenue and financial performance, projected costs, prospects, changes in management, plans and objectives of management are forward-looking statements. The words 鈥渁nticipate,鈥� 鈥渂elieve,鈥� 鈥渆stimate,鈥� 鈥渆xpect,鈥� 鈥渋ntend,鈥� 鈥渕ay,鈥� 鈥減lan,鈥� 鈥渨ould,鈥� 鈥渢arget鈥� and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Our actual future performance may materially differ from that contemplated by the forward-looking statements as a result of a variety of factors including, among other things, factors discussed under the heading 鈥淩isk Factors鈥� in our filings with the SEC. Except as expressly required by law, the Company disclaims any intent or obligation to update these forward-looking statements.听

Acknowledgements:
The U.S. Army Medical Research Acquisition Activity, 808 Schreider Street, Fort Detrick MD 21702-5014 is the awarding and administering acquisition office.鈥� This work was supported by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense, in the amount of $6,237,445 through the Peer Reviewed Medical Research Program under Award Number (HT9425-24-1-0233). Opinions, interpretations, conclusions, and recommendations are those of the author(s) and are not necessarily endorsed by The Assistant Secretary of Defense for Health Affairs endorsed by the Department of Defense. In conducting research using animals, the investigator(s) adhere(s) to the laws of the United States and regulations of the Department of Agriculture.

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