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Horizon Technology Finance Provides $35 Million Venture Loan Facility to Onkos Surgical® to Accelerate Commercialization of Novel Antibacterial Implant Technology

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Horizon Technology Finance (NASDAQ: HRZN) has provided a $35 million venture loan facility to Onkos Surgical, with $30 million initially funded. The funding will accelerate manufacturing and commercialization of Դǰ™, an FDA-granted antibacterial coating technology for orthopedic implants.

NanoCept received the first-ever FDA De Novo authorization for an antibacterial coating technology on orthopedic implants in April 2024. The technology has demonstrated up to 99.999% kill rate in standardized in-vitro testing of common operating room bacteria. Onkos Surgical, backed by investors including 1315 Capital, Canaan Partners, and SV Health Investors, operates in a $3 billion market developing solutions for adult and pediatric patients with bone loss from tumor, trauma, or failed orthopedic implant revision.

Horizon Technology Finance (NASDAQ: HRZN) ha fornito una linea di prestiti per venture capital di 35 milioni di dollari a Onkos Surgical, con 30 milioni inizialmente finanziati. Il finanziamento accelera la produzione e la commercializzazione di Դǰ™, una tecnologia di rivestimento antibatterico approvata dalla FDA per impianti ortopedici.

NanoCept ha ricevuto la prima autorizzazione De Novo della FDA per una tecnologia di rivestimento antibatterico su impianti ortopedici nell'aprile 2024. La tecnologia ha dimostrato un tasso di uccisione fino al 99,999% in test in vitro standardizzati su batteri comuni delle sale operatorie. Onkos Surgical, sostenuta da investitori tra cui 1315 Capital, Canaan Partners e SV Health Investors, opera in un mercato da 3 miliardi di dollari sviluppando soluzioni per pazienti adulti e pediatrici con perdita ossea dovuta a tumori, traumi o revisioni di impianti ortopedici fallite.

Horizon Technology Finance (NASDAQ: HRZN) ha proporcionado una línea de préstamo de capital de riesgo de 35 millones de dólares a Onkos Surgical, con 30 millones inicialmente financiados. La financiación acelerará la fabricación y comercialización de Դǰ™, una tecnología de recubrimiento antibacteriano aprobada por la FDA para implantes ortopédicos.

NanoCept recibió la primera autorización De Novo de la FDA para una tecnología de recubrimiento antibacteriano en implantes ortopédicos en abril de 2024. La tecnología ha demostrado una tasa de eliminación de hasta el 99,999% en pruebas in vitro estandarizadas de bacterias comunes en quirófanos. Onkos Surgical, respaldada por inversionistas que incluyen 1315 Capital, Canaan Partners y SV Health Investors, opera en un mercado de 3 mil millones de dólares desarrollando soluciones para pacientes adultos y pediátricos con pérdida ósea debido a tumores, traumas o revisiones fallidas de implantes ortopédicos.

Horizon Technology Finance (NASDAQ: HRZN)는 Onkos Surgical에 3,500만 달러의 벤처 대출 시설을 제공했으며, 3,000만 달러가 처음에 자금을 지원받았습니다. 이 자금은 Դǰ™의 제조 및 상용화를 가속화할 것입니다. NanoCept는 FDA로부터 승인받은 정형외과 임플란트를 위한 항균 코팅 기술입니다.

NanoCept는 2024년 4월 정형외과 임플란트에 대한 항균 코팅 기술로 FDA의 최초 De Novo 승인을 받았습니다. 이 기술은 일반 수술실 세균에 대한 표준화된 인 비트로 테스트에서 최대 99.999%의 살균율을 입증했습니다. 1315 Capital, Canaan Partners, SV Health Investors 등의 투자자들 지원을 받는 Onkos Surgical은 종양, 외상, 또는 실패한 정형외과 임플란트 수술의 결과로 뼈 손실을 가진 성인과 소아 환자들을 위한 솔루션을 개발하는 30억 달러 규모의 시장에서 활동하고 있습니다.

Horizon Technology Finance (NASDAQ: HRZN) a fourni une ligne de crédit de 35 millions de dollars à Onkos Surgical, dont 30 millions ont été financés initialement. Ce financement va accélérer la fabrication et la commercialisation de Դǰ™, une technologie de revêtement antibactérien approuvée par la FDA pour les implants orthopédiques.

NanoCept a reçu la première autorisation De Novo de la FDA pour une technologie de revêtement antibactérien sur des implants orthopédiques en avril 2024. La technologie a démontré un taux d’élimination allant jusqu'à 99,999% lors de tests in vitro standardisés sur des bactéries courantes en salle d’opération. Onkos Surgical, soutenue par des investisseurs tels que 1315 Capital, Canaan Partners et SV Health Investors, opère sur un marché de 3 milliards de dollars, développant des solutions pour les patients adultes et pédiatriques souffrant de perte osseuse due à des tumeurs, des traumatismes ou des révisions d'implants orthopédiques échouées.

Horizon Technology Finance (NASDAQ: HRZN) hat eine Venture-Darlehensfazilität in Höhe von 35 Millionen US-Dollar an Onkos Surgical bereitgestellt, wobei zunächst 30 Millionen US-Dollar finanziert wurden. Die Finanzierung wird die Herstellung und Kommerzialisierung von Դǰ™, einer von der FDA genehmigten antibakteriellen Beschichtungstechnologie für orthopädische Implantate, beschleunigen.

NanoCept erhielt im April 2024 die erste FDA De Novo Genehmigung für eine antibakterielle Beschichtungstechnologie an orthopädischen Implantaten. Die Technologie hat eine Sterberate von bis zu 99,999% in standardisierten In-vitro-Tests mit häufigen Operationssaal-Bakterien nachgewiesen. Onkos Surgical, unterstützt von Investoren wie 1315 Capital, Canaan Partners und SV Health Investors, ist in einem Markt von 3 Milliarden Dollar tätig, der Lösungen für erwachsene und pädiatrische Patienten mit Knochenschwund aufgrund von Tumoren, Traumata oder fehlgeschlagenen orthopädischen Implantatrevisionen entwickelt.

Positive
  • Secured $35 million venture loan facility with $30 million initially funded
  • First-ever FDA De Novo authorization for antibacterial coating technology (April 2024)
  • Technology demonstrates 99.999% bacteria kill rate in testing
  • Operating in a substantial $3 billion market
Negative
  • None.

Insights

This $35 million venture loan facility to Onkos Surgical represents a strategic move for HRZN's portfolio. The deal structure, with $30 million initially funded, provides immediate capital deployment while maintaining flexibility. The target market size of $3 billion for complex orthopedic procedures suggests significant revenue potential. The involvement of prestigious VC firms like Canaan Partners and SV Health Investors adds credibility to Onkos's business model. The FDA De Novo authorization for NanoCept creates a strong competitive moat and first-mover advantage in the antibacterial coating technology space. This venture debt deal aligns with HRZN's focus on high-growth healthcare technology companies and should generate attractive risk-adjusted returns through interest income and potential warrant coverage.

The NanoCept technology addresses a critical unmet need in orthopedic surgery with its 99.999% bacterial kill rate in standardized testing. This is particularly valuable given the devastating clinical and financial implications of implant-associated infections. The FDA De Novo authorization is especially noteworthy as it represents the first approval in this category, establishing regulatory precedent. The broad-spectrum efficacy against common operating room bacteria, combined with demonstrated safety and biocompatibility, positions NanoCept as a potential new standard of care. The technology's application across adult and pediatric patients, including complex cases involving tumor, trauma and revision surgeries, suggests substantial market penetration potential.

The timing of this funding is strategic as healthcare systems increasingly focus on reducing complications and associated costs. The antibacterial coating technology market represents a high-growth segment within medical devices, driven by rising infection rates and growing implant procedures. Onkos's positioning in complex orthopedic procedures, particularly in oncology and revision surgeries, targets high-value market segments. The backing by established healthcare investors validates the market opportunity and commercialization strategy. Early market entry with FDA authorization creates significant barriers to entry and positions Onkos to capture substantial market share in this emerging segment.

FARMINGTON, Conn.--(BUSINESS WIRE)-- Horizon Technology Finance Corporation (NASDAQ: HRZN) (“Horizon” or the “Company”), an affiliate of Monroe Capital, and a leading specialty finance company that provides capital in the form of secured loans to venture capital-backed companies in the technology, life science, healthcare information and services, and sustainability industries, today announced it has provided a $35 million venture loan facility to Onkos Surgical (“Onkos”), of which $30 million has been initially funded.

Onkos intends to use the proceeds of the loan facility to accelerate manufacturing and commercialization of Դǰ™, a groundbreaking, antibacterial coating technology that is used on FDA-granted orthopaedic implants to reduce bacterial contamination at the time of implantation. Bacterial contamination of implants is a significant clinical challenge that can have devastating implications for patients and poses a substantial financial burden to the healthcare system.

“Onkos Surgical is disrupting the orthopaedic marketplace with a suite of differentiated products, including NanoCept,” said Gerald A. Michaud, President of Horizon. “We are pleased to support the growth of Onkos as it continues to innovate novel solutions that address diverse unmet needs in a growing and important market segment.”

Onkos Surgical is a leading innovator in the musculoskeletal space, developing technologies to address the clinical challenges associated with complex orthopaedic procedures. The company’s portfolio of products provides solutions for adult and pediatric patients who have bone loss from tumor, trauma, or revision of failed orthopaedic implants. In , NanoCept was granted the first-ever FDA De Novo authorization for an antibacterial coating technology used on orthopaedic implants, demonstrating Onkos’s innovation capabilities. NanoCept has demonstrated excellent safety and biocompatibility, with broad-spectrum efficacy (up to 99.999% kill rate in standardized in-vitro testing of bacteria commonly found in the operating room environment). Onkos is backed by top-tier investors including 1315 Capital, Canaan Partners, and SV Health Investors.

“We are committed to transforming the standard of care across complex orthopaedic procedures, with the goals of providing benefit to patients, clinicians, and health systems while creating value for our investors as we expand our footprint in a $3 billion market,” said Patrick Treacy, Onkos Surgical CEO and Co-founder. “Horizon’s support will further fuel our growth engine by accelerating the commercialization of NanoCept, a transformative and first-of-its-kind orthopaedic technology that has substantial potential to meaningfully improve patient outcomes.”

About Horizon Technology Finance

Horizon Technology Finance Corporation (NASDAQ: HRZN), externally managed by Horizon Technology Finance Management LLC, an affiliate of Monroe Capital, is a leading specialty finance company that provides capital in the form of secured loans to venture capital-backed companies in the technology, life science, healthcare information and services, and sustainability industries. The investment objective of Horizon is to maximize its investment portfolio’s return by generating current income from the debt investments it makes and capital appreciation from the warrants it receives when making such debt investments. Horizon is headquartered in Farmington, Connecticut, with a regional office in Pleasanton, California, and investment professionals located throughout the U.S. Monroe Capital is a $19.4 billion asset management firm specializing in private credit markets across various strategies, including direct lending, technology finance, venture debt, opportunistic, structured credit, real estate and equity. To learn more, please visit .

About Onkos Surgical

Onkos Surgical is a leader in innovative solutions for complex orthopaedic conditions. With our novel product portfolio, surgeons are better informed about patient-specific clinical challenges and can plan and implement more precise reconstructions. Our personalized approach supports improved patient outcomes and experiences using the latest innovations in antibacterial implant coatings, virtual surgical planning, 3D anatomic modeling and printing, implant design, and workflow optimization. More than 350 of the leading academic medical institutions in the US choose Onkos for their complex revision and tumor orthopaedic cases. For more information on Onkos Surgical and its products and services, please visit .

Forward-Looking Statements

Statements included herein may constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Statements other than statements of historical facts included in this press release may constitute forward-looking statements and are not guarantees of future performance, condition or results and involve a number of risks and uncertainties. Actual results may differ materially from those in the forward-looking statements as a result of a number of factors, including those described from time to time in the Company’s filings with the Securities and Exchange Commission. Horizon undertakes no duty to update any forward-looking statement made herein. All forward-looking statements speak only as of the date of this press release.

Investor Relations:

ICR

Garrett Edson

ir@horizontechfinance.com

(646) 200-8885

Media Relations:

ICR

Chris Gillick

HorizonPR@icrinc.com

(646) 677-1819

Source: Horizon Technology Finance Corporation

FAQ

What is the size of Horizon Technology Finance's (HRZN) loan facility to Onkos Surgical?

Horizon Technology Finance provided a $35 million venture loan facility to Onkos Surgical, with $30 million initially funded.

When did Onkos Surgical receive FDA De Novo authorization for NanoCept?

Onkos Surgical received FDA De Novo authorization for NanoCept, their antibacterial coating technology for orthopedic implants, in April 2024.

What is the bacterial kill rate of Onkos Surgical's NanoCept technology?

NanoCept has demonstrated up to 99.999% kill rate in standardized in-vitro testing of bacteria commonly found in the operating room environment.

What is the market size for Onkos Surgical's products?

Onkos Surgical operates in a $3 billion market segment.

Who are the major investors backing Onkos Surgical?

Onkos Surgical is backed by top-tier investors including 1315 Capital, Canaan Partners, and SV Health Investors.

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